Senior Scientist - Targeted Lipid Nanoparticle Delivery

We are seeking a

Senior Scientist

to join the Non-viral Delivery Technologies team, part of Regeneron Genetic Medicines (RGM), to support the efforts to target lipid nanoparticles (LNP) and other nanocarriers to extrahepatic tissues. You will spearhead projects to develop methods to systemically evaluate targeting ligands, such as antibodies, peptides, or small molecules, for their ability to direct nanocarriers to desired cells and tissues of interest. You will help define the ?rules? for choosing antibodies that enable successful targeting of LNPs and other nanocarriers, including parameters such as receptor copy number, receptor biology, internalization kinetics and compartments, cell expression profiles, desired binding properties, and avidity/affinity driven uptake. These rules will be critically analyzed to determine how they relate to other targeted payloads, such as AAVs, siRNAs, or proteins. We hope you are excited to work closely with disease biology teams across multiple therapeutic areas to implement these technology advancements into Regeneron?s therapeutic pipeline.

As a Senior Scientist, a typical day might include:

Performing in vitro and primary cell culture assays to characterize properties of targeting, internalization, potency, including multicolor flow cytometry (10+ colors), intracellular fluorescence microscopy, and reporter assays

Conducting functional in vivo assays of delivery/efficacy, including multicolor flow cytometry, in vivo luminescence/fluorescence, and ISH-based techniques

Determining the specific and generalizable rules of targeted LNPs for ongoing and future preclinical program antibodies and ligands

Collaborating with chemistry teams to produce, test and screen formulation/conjugation changes in nanocarriers

Developing and implementing medium throughput assays to screen antibodies in vitro and in vivo

Interpreting and presenting results at group and departmental meetings

Keeping up-to-date with relevant scientific literature and conferences

This role might be for you if you:

Are excited and enjoy working hands-on at the bench

Are passionate about developing next-generation lipid nanoparticles and other future nanocarriers

Enjoy working in an innovative and highly collaborative environment

Are adaptable and able to shift priorities and project focuses frequently as scientific understanding evolves

Have strong organizational, time-management, and communication skills

In order to be considered for this role , you must have at least a Ph.D. and 0-2 years of relevant post-Ph.D. experience or a BS/MS and 8-10+ years of relevant experience. We need someone with a firm understanding of biological principles related to internalization, receptor trafficking, and ligand targeting. In vitro and in vivo experience in nanocarrier development is required. Experience with LNP fabrication is highly desired. Familiarity with alternative antibody formats is preferred. The ability to interface and work collaboratively between biologists and chemists is essential to succeed in this role.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$108,300.00 - $176,700.00