Entrepreneur-in-Residence (EIR), Liquid Biopsy Services

The Company

We are Alloy Therapeutics ?a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.

Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of ?Mentorship-By-Apprenticeship? in all of our positions.??We strive to have workers in the office when needed to interact organically and face-to-face.??Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year.??We respect and value our colleagues for their hard work that requires them to be in the lab every day.??We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility.??We are all one team!

The Team

The Office of the CEO at Alloy Therapeutics functions as a strategic thought partner across the executive leadership team. It drives and manages a broad range of corporate priorities to advance the Alloy ecosystem. The OCEO:

• Partners directly with C-suite leaders to facilitate high-priority initiatives.
• Coordinates execution across the company, aligning efforts across Business Development, Scientific, Legal, Finance, and Venture Creation.
• Delivers tools, processes, and analyses that support strategic decision-making and execution at all levels of the organization - including across Alloy and its affiliated venture studio, 82VS

The Role

We are seeking an experienced Entrepreneur-in-Residence (EIR) to lead the development and launch of a clinical testing service focused on circulating tumor DNA (ctDNA) analysis in liquid biopsies. This role will be responsible for defining and implementing a differentiated service offering that leverages cutting-edge, ultra-high-sensitivity sequencing technologies to support oncology product development, translational research, and clinical decision-making.

The EIR will operate at the intersection of technology, clinical diagnostics, and business strategy, with the mandate to assess market opportunity, establish technical and operational foundations, and ultimately build a scalable clinical testing platform aligned with current and future oncology product offerings.

How You'll Drive Impact

• Develop: The strategic vision, value proposition, and business model for a ctDNA-based clinical testing service.
• Lead: Selection, development, and implementation of high-sensitivity clinical testing assays.
• Drive: Establishment and scaling of CLIA/CAP-compliant clinical testing laboratories.
• Partner: With regulatory and payer experts to define reimbursement and commercial strategy
• Collaborate: Closely with internal and external stakeholders to ensure clinical testing services are tightly aligned with Alloy Therapeutics? broader drug development strategy.

Principal Responsibilities

Service & Business Development

• Define priority indications and clinical contexts where ctDNA provides clear decision-making value (e.g., MRD, therapy monitoring, resistance).
• Determine optimal platform strategy across assay development, sequencing technologies, and bioinformatics (build, partner, or acquire).
• Design commercial models and customer engagement strategies for biopharma, clinical trial, and healthcare delivery settings.

Technology & Assay Strategy

• Select and operationalize ultra-sensitive sequencing and error-correction approaches appropriate for each clinical use case.
• Establish analytical performance benchmarks and validation frameworks to ensure robust, reproducible results.
• Drive assay lifecycle management, including optimization, scalability, and turnaround times suitable for prospective clinical use.
• Guide bioinformatics and variant interpretation approaches for ultra-low allele frequency detection.

Clinical & Regulatory Enablement

• Implement CLIA/CAP laboratory workflows and quality systems to support clinical testing deployment.
• Define regulatory positioning across LDTs, clinical trial support, companion diagnostics, and future IVD pathways.
• Partner with reimbursement and health-economics experts to develop evidence strategies supporting payer adoption.

Cross-Functional Leadership

• Align clinical testing priorities with Alloy's discovery, translational, and clinical development teams.
• Coordinate external partnerships with academic centers, technology providers, CROs, and clinical sites.
• Recruit and develop early technical, clinical, and operational team members.

Venture Creation & Scale-Up

• Build operating and financial plans to support growth from initial deployment to scaled clinical service.
• Support strategic partnerships, fundraising activities, and evaluation of spin-out or standalone company opportunities.
• Assume increasing leadership responsibility as the platform matures, with potential transition into a senior executive role.

Qualifications

• Former or aspiring founder with domain expertise in liquid biopsy or oncology diagnostics.
• Experience working with biopharma partners on translational or clinical trial assays.
• Comfortable operating in ambiguity and building from zero to one.
• PhD, MD, or equivalent advanced degree in molecular biology, genomics, oncology, pathology, or related field.
• 10+ years of experience in liquid biopsy, ctDNA analysis, clinical genomics, or molecular diagnostics.
• Deep hands-on or leadership experience with high-sensitivity sequencing technologies for rare variant detection.
• Strong understanding of clinical assay validation, CLIA/CAP lab operations, and regulatory considerations.
• Demonstrated entrepreneurial mindset with experience launching new products, platforms, or services.
• Ability to bridge scientific depth with commercial and strategic thinking.
• Excellent communication skills with the ability to engage scientific, clinical, and investor audiences.
• Ability to work across various US and international time zones
• Accommodate occasional travel as needed (10%)

Desired Multipliers

• Former or aspiring founder with domain expertise in liquid biopsy or oncology diagnostics.
• Experience working with biopharma partners on translational or clinical trial assays.
• Comfortable operating in ambiguity and building from zero to one.
• Motivated by impact in precision oncology and early cancer detection.

Taking Care of Our People

We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you're single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.

Compensation

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match

Health & Family

• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)

Unique Perks

• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

Alloy Therapeutics is an equal opportunity employer. ? All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status.? If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com .? We will make every effort to respond to your request for disability assistance as soon as possible.

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